![]() This rare abnormality accompanies various malformations of the brain that affect. It is connected to the corpus callosum - a collection of nerve fibers that connect the cerebral hemispheres. In today’s chimeric RNA research, there are still several key flaws, technical constraints and understudied tasks, which are also described in this perspective essay. The septum pellucidum (SP) is a thin membrane located at the midline of the brain between the two cerebral hemispheres, or halves of the brain. Many RNAs containing sequences of two neighboring genes may be transcribed via a readthrough mechanism, and thus are actually RNAs of unannotated genes or RNA variants of known genes, but not chimeras. We propose that only those RNAs that are formed by joining two RNA transcripts together without a fusion gene as a genomic basis should be regarded as authentic chimeras, whereas those RNAs transcribed as, and cis-spliced from, single transcripts should not be deemed as chimeras. The word ‘pellucid’, meaning clear, was first used by Schlaeppi 1 to denote the clarity of the cornea in this condition despite the presence of ectasia. Otherwise, not only will chimeric RNA studies be misled but also characterization of fusion genes and unannotated genes will be hindered. Pellucid marginal corneal degeneration (PMD) is a rare idiopathic, thinning disorder of the peripheral cornea most usually affecting the inferior quadrant in a crescentic fashion. Since the number of putative chimeras is soaring, it is imperative to establish a pellucid definition for it, in order to differentiate chimeras from regular RNAs. However, “chimeric RNA” has never been lucidly defined, partly because “gene” itself is still ill-defined and because the means of production for many RNAs is unclear. The cells of the posterior marginal zone and of Kollers sickle are in direct contact with the underlying yolk, whilst the area pellucida, which is anterior to. The meaning of TRANSPARENT is having the property of transmitting light without appreciable scattering so that bodies lying beyond are seen clearly : pellucid. ![]() There have been tens of thousands of RNAs deposited in different databases that contain sequences of two genes and are coined chimeric RNAs, or chimeras.
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